Data di Pubblicazione:
1995
Citazione:
IDENTIFICATION AND FULL CHARACTERIZATION OF A NEW METABOLITE OF
METOCLOPRAMIDE / V. Maurich, M. De Amici, C. De Micheli, P. Rossato. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 30:10(1995), pp. 757-762.
Abstract:
The metabolism of metoclopramide 1 has been reinvestigated by HPLC
coupled with mass spectrometry. The urine of healthy volunteers showed
the presence of a new metabolite 2 derived from the enzymatic oxidation
of the primary aromatic amino group of 1 to the hydroxylamino moiety.
The structure of the new metabolite was ascertained by its fragmentation
pattern in the mass spectrometer and unambiguously secured by an
independent synthesis. In addition, the tertiary amine group of 1 was
selectively oxidized to the corresponding N-oxide. This compound and its
ring oxidation metabolites were not detected in the urine of the tested
volunteers.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
arylhydroxylamino derivative; metabolite; metoclopramide metabolism; metoclopramide N-oxide
Elenco autori:
V. Maurich, M. De Amici, C. De Micheli, P. Rossato
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