Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives
Articolo
Data di Pubblicazione:
1996
Citazione:
Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives / C. Felli, G. Carrea, M. Chiari, M. De Amici, C. De Micheli. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 741:2(1996), pp. 287-294.
Abstract:
The enantiomeric separation of some muscarinic antagonists bearing a
quaternary ammonium group was investigated by using capillary
electrophoresis. The effects of alpha-, beta-, gamma-cyclodextrin
concentration were studied in an attempt to resolve all the analytes.
The use of a coated capillary was found to be essential to improve
resolution, efficiency and reproducibility of the separation profile,
The sensitivity limit for enantiomeric concentration was as low as 1\%
and the response was linear after correction for time migration.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Buffer composition; Cyclodextrins; Enantiomer separation; Muscarinic ligands; Quaternary ammonium compounds
Elenco autori:
C. Felli, G. Carrea, M. Chiari, M. De Amici, C. De Micheli
Link alla scheda completa: