Pharmacological profile of enantiomerically pure chiral muscarinic agonists - Desoxymuscarines
Articolo
Data di Pubblicazione:
2000
Citazione:
Pharmacological profile of enantiomerically pure chiral muscarinic
agonists - Desoxymuscarines / M. De Amici, C. Dallanoce, C. De Micheli, P. Angeli, G. Marucci, F. Cantalamessa, L. Sparapassi. - In: LIFE SCIENCES. - ISSN 0024-3205. - 67:3(2000), pp. 317-326.
Abstract:
The enantiomers desoxymuscarine 6 were tested in vitro on guinea pig tissues, and their muscarinic potency was evaluated at M2 (heart force and rate) and M3 (ileum and bladder) receptor subtypes together with the enantiomers of the parent compound muscarine 1. The eutomers (+)-1 and (+)-6 and distomers (-)-1 and (-)-6 were also assayed in vivo on pithed rat. Affinity, relative efficacy and enantio-selectivity were also determined for the compounds under study at M2 (heart force and rate) and M3 (ileum and bladder), in order to investigate muscarinic receptor heterogeneity. The results of this study have been discussed in comparison with the data previously reported for the structurally related fluoromuscarine (+)-4 and difluoromuscarines (+)-5 and (-)-5. (C) 2000 Elsevier Science Inc.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. De Amici, C. Dallanoce, C. De Micheli, P. Angeli, G. Marucci, F. Cantalamessa, L. Sparapassi
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