New analogues of oxotremorine and oxotremorine-M - Estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes
Articolo
Data di Pubblicazione:
2000
Citazione:
New analogues of oxotremorine and oxotremorine-M - Estimation of their
in vitro affinity and efficacy at muscarinic receptor subtypes / E. Barocelli, V. Ballabeni, S. Bertoni, C. Dallanoce, M. De Amici, C. De Micheli, M. Impicciatore. - In: LIFE SCIENCES. - ISSN 0024-3205. - 67:6(2000), pp. 717-723.
Abstract:
Two subsets of tertiary amines (1a-6a) and methiodides (1b-6b) with a structural resemblance to oxotremorine and oxotremorine-M were tested at rabbit vas deferens (M1), guinea pig left atrium (M2), guinea pig ileum and urinary bladder (M3) muscarinic receptor subtypes. The pharmacological profile of the derivatives under study has been discussed by evaluating their potency, affinity and efficacy as well as the regional differences in muscarinic receptor occupancy. (C) 2000 Elsevier Science Inc.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Functional determination of affinity and efficacy; Muscarinic agonists; Oxotremorine
Elenco autori:
E. Barocelli, V. Ballabeni, S. Bertoni, C. Dallanoce, M. De Amici, C. De Micheli, M. Impicciatore
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