Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation
Articolo
Data di Pubblicazione:
1998
Citazione:
Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation / D. Colombo, A. Scala, I. Taino, L. Toma, F. Ronchetti, H. Tokuda, H. Nishino, A. Nagatsu, J. Sakakibara. - In: CANCER LETTERS. - ISSN 0304-3835. - 123:1(1998), pp. 83-86.
Abstract:
In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-β-D-glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C4 to C18 were examined for their in vitro anti-tumor promoting effects on Epstein-Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anti-tumor promoters; Cancer chemoprevention; Epstein-Barr virus early antigen; Glycosylglycerols
Elenco autori:
D. Colombo, A. Scala, I. Taino, L. Toma, F. Ronchetti, H. Tokuda, H. Nishino, A. Nagatsu, J. Sakakibara
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