Data di Pubblicazione:
2001
Citazione:
Diesters of glycosylglycerols active in cancer chemoprevention / D. Colombo, F. Compostella, F. Ronchetti, A. Scala, H. Tokuda, H. Nishino. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 36:7-8(2001), pp. 691-695.
Abstract:
Enzymatic transesterification, mediated by Pseudomonas cepacia lipase (lipase PS), led to the pure 1,6′-diacylderivatives of 2-O-β-D-glucosyl-sn-glycerol and 2-O-β-D-galactosyl-sn-glycerol, the acyl chains being derived from short-medium length fatty acids. A study of the in vitro inhibitory effects of these diacylderivatives on Epstein-Barr virus early antigen activation induced by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate revealed that maximum activity was reached for the hexanoyl chain and that the introduction of a second acyl chain did not significantly modify the inhibitory potential referring to the corresponding 1- or 6′-monoesters.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cancer chemoprevention; Epstein-Barr virus early antigen; Glycoglycerolipids; Lipase
Elenco autori:
D. Colombo, F. Compostella, F. Ronchetti, A. Scala, H. Tokuda, H. Nishino
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