Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion
Articolo
Data di Pubblicazione:
2002
Citazione:
Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion / D. Colombo, F. Compostella, F. Ronchetti, S. Reza-Elahi, A. Scala, L. Toma, W. Aoi, M. Kuchide, J. Takayasu, H. Tokuda, H. Nishino. - In: CANCER LETTERS. - ISSN 0304-3835. - 186:1(2002), pp. 37-41. [10.1016/S0304-3835(02)00336-1]
Abstract:
Nine new synthetic compounds, structurally related to the most active glycoglycerolipid analogues carrying a hexanoyl chain, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus (EBV) activation. All these compounds, in which the ester function is replaced by different metabolically more stable groups, were almost as active as their ester reference compounds in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Two of these, devoid of any functionality on the lipophilic chain, when tested in an in vivo two-stage carcinogenesis test, exhibited marked inhibitory effects on mouse skin tumor promotion.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
12-O-tetradecanoylphorbol-13-acetate; Cancer chemoprevention; Epstein-Barr virus; Glycoglycerolipids; Two-stage skin carcinogenesis test
Elenco autori:
D. Colombo, F. Compostella, F. Ronchetti, S. Reza Elahi, A. Scala, L. Toma, W. Aoi, M. Kuchide, J. Takayasu, H. Tokuda, H. Nishino
Link alla scheda completa: