Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone
Articolo
Data di Pubblicazione:
2003
Citazione:
Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone / D. Colombo, F. Ronchetti, A. Scala, L. Toma, H. Tokuda, H. Nishino. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 11:6(2003), pp. 909-912.
Abstract:
Glycoglycerolipid analogues lacking the glycerol backbone were prepared through a lipase catalyzed transesterification of β-D-galactosylethylene glycol. The inhibitory effect of the resultant isomeric hexanoates at the primary alcoholic positions, β-D-galactosylethylene glycol itself and nonyl β-D-galactopyranoside, was tested on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), as a primary screening test for inhibitors of tumor promotion. All the compounds assayed were found to be less active than the reference 2-O-β-D-galactopyranosylglycerol derivatives, of which they are simplified models, indicating that the anti-tumor-promoting activity is very closely related to the presence of a free hydroxymethylene group on the glycerol-like aglycone moiety.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Colombo, F. Ronchetti, A. Scala, L. Toma, H. Tokuda, H. Nishino
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