GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk
Articolo
Data di Pubblicazione:
1999
Citazione:
GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk / M Panigada, S Porcellini, F Sutti, L Doneda, O Pozzoli, GG Consalez, M Guttinger, F Grassi. - In: MECHANISMS OF DEVELOPMENT. - ISSN 0925-4773. - 81:1-2(1999), pp. 103-113.
Abstract:
Gut-enriched Kruppel-like factor (GKLF) is a transcriptional regulator expressed in differentiated epithelia. We identified GKLF transcript as a regulated element in thymic epithelium of recombinase-deficient mice during thymus development induced by anti-CD3 antibody injection. This treatment recapitulates the organogenetic process depending on productive rearrangement of T cell receptor (TCR) β gene with thymocytes expansion and acquisition of the CD4+8+ double positive phenotype. In wildtype mice, GKLF is expressed very early in embryogenesis and becomes intensely up-regulated in thymus epithelium at day 18 of gestation when TCR β expressing cells have selectively expanded and express both CD4 and CD8. The results presented here suggest that thymocytes may regulate GKLF transcriptionally in the cortical epithelium at the developmental check-point controlled by TCR β gene rearrangement. Furthermore, GKLF expression in hematopoietic stroma might suggest the thus far uncharacterised participation of this factor in hematopoiesis.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M Panigada, S Porcellini, F Sutti, L Doneda, O Pozzoli, GG Consalez, M Guttinger, F Grassi
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