Data di Pubblicazione:
2001
Citazione:
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages / W. Ponti, T. Rubino, M. Bardotti, G. Poli, D. Parolaro. - In: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0165-2427. - 82:3-4(2001), pp. 203-214.
Abstract:
Feline immunodeficiency virus (FIV) infection causes a widespread natural immunodeficiency syndrome in cats that is considered a suitable animal model for studying human immunodeficiency virus (HIV) infection and pathogenesis, Short term cultures of bone marrow derived feline macrophages stimulated with recombinant feline interferon-gamma (r-IFN-gamma) and lipopolysaccharide (LPS) were shown to produce nitric oxide. Feline macrophages were shown to express cannabinoid receptors, and nitric oxide production decreased after in vitro exposure to synthetic cannabinoid CP-55940. Both cannabinoid receptors, CB1 and CB2, were involved in this process, since the inhibition was reversed by selective cannabinoid antagonists for both of these receptors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cat ; macrophage cultures ; nitric oxide ; cannabinoids
Elenco autori:
W. Ponti, T. Rubino, M. Bardotti, G. Poli, D. Parolaro
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