DECREASE IN HEPATIC-MICROSOMAL UDP-GLUCURONOSYL-TRANSFERASE ACTIVITY IN RATS AND CATTLE WITH FASCIOLIASIS - IMPAIRED INVITRO GLUCURONIDATION OF OXYCLOZANIDE
Articolo
Data di Pubblicazione:
1985
Citazione:
DECREASE IN HEPATIC-MICROSOMAL UDP-GLUCURONOSYL-TRANSFERASE ACTIVITY IN RATS AND CATTLE WITH FASCIOLIASIS - IMPAIRED INVITRO GLUCURONIDATION OF OXYCLOZANIDE / R. Maffei Facino, M. Carini, C. Genchi. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 26:1(1985), pp. 65-71.
Abstract:
The effects of liver fluke infection (Fasciola hepatica) on hepatic microsomal UDP-glucuronosyltransferase activity have been studied in microsomes from experimentally infected rats and naturally infected cattle to see if they explain the toxic episodes observed in parasite-infected animals subjected to intensive chemotherapy with the flukicidal drug oxyclozanide. Dramatic decreases in the activity of this enzyme system with the typical substrate p-nitrophenol were observed in both animal species, even when little or no degenerative lesions could be seen in the liver parenchyma. In vitro there was a similar loss of glueuronic acid conjugation of oxyclozanide by hepatic microsomes from infected cattle. In vivo this would result in slower elimination of the drug and in drug accumulation.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Maffei Facino, M. Carini, C. Genchi
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