Data di Pubblicazione:
1992
Citazione:
Effects of ovarian hormones on brain opioid binding sites in castrated female rats / D. Dondi, P. Limonta, R. Maggi, F. Piva. - In: AMERICAN JOURNAL OF PHYSIOLOGY. - ISSN 0002-9513. - 263:3 Pt 1(1992 Sep), pp. E507-E511.
Abstract:
These experiments were performed to analyze whether treatments of ovariectomized female rats with ovarian steroid regimens able to induce either an increase (positive feedback effect) or a decrease (negative feedback effect) of serum levels of luteinizing hormone (LH) have some impact on the characteristics of mu-opioid binding sites in circumscribed areas of the brain. The increase of serum levels of LH elicited by a treatment with estradiol benzoate (EB) plus progesterone (P; positive feedback effect) was accompanied by a significant decrease in the number of mu-binding sites in the hypothalamus and in the corpus striatum. The decrease in serum levels of LH induced by a treatment with EB alone (negative feedback effect) brought about a significant increase of the number of mu-binding sites in the thalamus and in the hippocampus. These results seem to suggest that the release of LH induced by EB plus P may involve a decrease of hypothalamic mu-binding sites. Apparently, the inhibitory effect on LH release exerted by EB alone does not involve any change of the density of these binding sites in the hypothalamus.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
μ-opioid binding sites; corpus striatum; estradiol; hippocampus; hypothalamus; luteinizing hormone; negative feedback effect of estradiol; positive feedback effect of estradiol plus progesterone; progesterone; thalamus
Elenco autori:
D. Dondi, P. Limonta, R. Maggi, F. Piva
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