Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats
Articolo
Data di Pubblicazione:
1981
Citazione:
Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats / N. Zonta, F. Zambotti, L. Vicentini, R. Tammiso, P. Mantegazza. - In: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. - ISSN 0028-1298. - 316:3(1981 Jun), pp. 231-234.
Abstract:
Intracerebroventricular administration of muscimol, a potent GABA-receptor agonist, counteracted the antinociceptive effect of morphine or beta-endorphin in rats as measured by the "tail flick" method. Muscimol's activity was reversed by bicuculline. Isoguvacine, another GABA agonist, as well as nipecotic acid and guvacine, two inhibitors of neuronal and glial uptake of GABA, also antagonized morphine's antinociceptive effect. A role of the central GABA-ergic system in mediating opiate antinociception is proposed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Isonicotinic Acids; Animals; Morphine; Drug Interactions; Nipecotic Acids; Bicuculline; beta-Endorphin; Endorphins; Rats; Nicotinic Acids; gamma-Aminobutyric Acid; Muscimol; Analgesics; Male
Elenco autori:
N. Zonta, F. Zambotti, L. Vicentini, R. Tammiso, P. Mantegazza
Link alla scheda completa: