Intestinal effect and analgesia: evidence for different involvement of opioid receptor subtypes in periaqueductal gray matter
Articolo
Data di Pubblicazione:
1986
Citazione:
Intestinal effect and analgesia: evidence for different involvement of opioid receptor subtypes in periaqueductal gray matter / D. Parolaro, G. Crema, M. Sala, A. Santagostino, G. Giagnoni, E. Gori. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 120:1(1986), pp. 95-99. [10.1016/0014-2999(86)90645-X]
Abstract:
Periaqueductal gray matter (PAG) has been shown to be one of the sites in the central nervous system where microinjections of morphine strongly inhibit intestinal transit. To investigate the nature of opioid receptor populations involved in this central effect, selective opioid agonists, FK33824 for μ, DALA for σ, dynorphin for κ and tentatively β-endorphin for ε{lunate}, were microinjected in all PAG areas previously identified as morphine-sensitive for intestinal inhibition. The PAG-induced inhibition of intestinal transit appears to be mediated mainly by μ receptors and possibly by ε{lunate} receptors. κ and σ receptors seem not to be involved.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Parolaro, G. Crema, M. Sala, A. Santagostino, G. Giagnoni, E. Gori
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