Data di Pubblicazione:
1986
Citazione:
[Pharmacologic activity of 1-lupinylquinoxalin-2(1H)-ones, 3,6-disubstituted] / M. Satta, A. Peana, A. Sparatore, M. C. Alamanni. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 41:9(1986 Sep), pp. 722-728.
Abstract:
Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Alkaloids; Lethal Dose 50; Quinoxalines; Exploratory Behavior; Physostigmine; Mice; Analgesics; Male; Female; Anticonvulsants
Elenco autori:
M. Satta, A. Peana, A. Sparatore, M. C. Alamanni
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