Data di Pubblicazione:
1988
Citazione:
[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine] / C. Boido-Canu, V. Boido, F. Sparatore, A. Sparatore, V. Susanna, S. Russo, M. L. Cenicola, E. Marmo. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 43:10(1988 Oct), pp. 819-837.
Abstract:
By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Chemistry; Pentylenetetrazole; Diuretics; Hemodynamics; Mice; Quinolizines; Rats; Indoles; Heart Rate; Pentobarbital; Muscle Relaxants, Central; Chemical Phenomena; Motor Activity; Anti-Inflammatory Agents, Non-Steroidal
Elenco autori:
C. Boido-Canu, V. Boido, F. Sparatore, A. Sparatore, V. Susanna, S. Russo, M. L. Cenicola, E. Marmo
Link alla scheda completa: