Data di Pubblicazione:
1986
Citazione:
[Quinolizidine derivatives with antibacterial activity] / A. Sparatore, A. Pesce Schito. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 41:10(1986 Oct), pp. 781-787.
Abstract:
Six quinolizidinyl-derivatives were tested for antibacterial actvity against a large number of gram-positive and gram-negative strains. 9-Lupinyliden-fluorene (I) and its epimer (II) at concentrations between 12,5 and 100 mg/l inhibit all gram-positive strains, while they are only weakly active against a few gram-negative bacteria. The tertiary alcohols (III) and (IV) are inactive against the gram-positive strains, while still exhibiting weak activity on the gram-negative. Compounds (V) and (VI) are completely inactive. The values of minimal bactericidal concentrations for compound (I) against the sensitive strains are equal to or no more than 4 times higher than values of MIC. It is interesting to note that compound (I) is able to give rise to cellular lysis at MIC.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bacteria; Anti-Bacterial Agents; Chemistry; Chemical Phenomena; Quinolizines; Microbial Sensitivity Tests
Elenco autori:
A. Sparatore, A. Pesce Schito
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