Data di Pubblicazione:
1983
Citazione:
New routes to A-ring substituted estrogens / E. Santaniello, P. Ferraboschi. - In: JOURNAL OF STEROID BIOCHEMISTRY. - ISSN 0022-4731. - 19:1 Part 3(1983), pp. 767-769.
Abstract:
Estrogens can be regiospecifically functionalized at the position 2 by a few electrophilic reagents. Reactions of estradiol 3-methyl ether-17 beta-acetate with Hg(OAc)2 and BF3 . Et2O/Ac2O allows the preparation of 2-chloromercurio- and 2-organoboron-derivatives respectively. Both the above compounds are useful starting material for easy preparations of 2-catecholestrogens and 2-chloromercurio-derivative can be transformed in other functionalized estrogens. New procedures for the preparation of 2,4-dinitroestrone and 2-nitroestrone are also described.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. Santaniello, P. Ferraboschi
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