Data di Pubblicazione:
2007
Citazione:
Cardiopulmonary interaction in heart failure / P. Agostoni, G. Cattadori, M. Bussotti, A. Apostolo. - In: PULMONARY PHARMACOLOGY & THERAPEUTICS. - ISSN 1094-5539. - 20:2(2007), pp. 130-4-134. [10.1016/j.pupt.2006.03.001]
Abstract:
In heart failure lung dysfunction is frequent and is greater the greater the heart failure severity. It can be evaluated in terms of lung mechanics and gas diffusion. Indeed heart-lung interaction is related to heart dimensions and lung fluid content; furthermore heart-lung interaction is influenced by the body position. Lung diffusion is also altered in patients with chronic heart failure, and a low gas diffusion is associated with a reduced performance. During exercise, heart-lung interaction becomes more evident. Heart failure patients show an abnormal hyperventilation due to a progressively increased respiratory rate, and a lower tidal volume; hyperventilation is due to different causes including enhanced responses from chemo- and metabolo-receptors, increased CO(2) production and increased dead space ventilation. Several drugs affect the ventilatory pattern in heart failure patients: ACE-inhibitors and anti-aldosteronic drugs improve lung diffusion and ventilatory efficiency during exercise; beta-blockers reduce exercise-induced hyperventilation. Furthermore, ultrafiltration improves lung mechanics, both at rest and during exercise, through body fluid content reduction.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cardiomegaly; Exercise; Heart failure
Elenco autori:
P. Agostoni, G. Cattadori, M. Bussotti, A. Apostolo
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