Data di Pubblicazione:
1990
Citazione:
Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level / H. H. van Tol, M. Riva, O. Civelli, I. Creese. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 111:3(1990 Apr 06), pp. 303-308.
Abstract:
The chronic treatment of rats with antipsychotic drugs which increase striatal D2 dopamine receptors did not measurably increase the level of D2 receptor mRNA indicating that the observed increase in receptors was not primarily due to transcriptional regulation. These and other data suggest that the molecular mechanisms involved in receptor regulation in response to denervation or neurotransmitter depletion may be different from those which occur in response to chronic receptor blockade by antagonist drugs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antipsychotic drug; Clozapine; D1 dopamine receptor; D2 dopamine receptor mRNA; Haloperidol; Raclopride; SCH23390
Elenco autori:
H. H. van Tol, M. Riva, O. Civelli, I. Creese
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