Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization
Articolo
Data di Pubblicazione:
1989
Citazione:
Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization / S. Colli, M. Marinovich, E. Stragliotto, C.L. Galli, E. Tremoli. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 38:22(1989), pp. 3909-3912.
Abstract:
Albumin, at concentration normally present in plasma (~ 600 μM), significantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Colli, M. Marinovich, E. Stragliotto, C.L. Galli, E. Tremoli
Link alla scheda completa: