Involvement of periaqueductal gray matter in intestinal effect of centrally administered morphine
Articolo
Data di Pubblicazione:
1983
Citazione:
Involvement of periaqueductal gray matter in intestinal effect of centrally administered morphine / M. Sala, D. Parolaro, G. Crema, L. Spazzi, G. Giagnoni, R. Cesana, E. Gori. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 91:2-3(1983), pp. 251-254. [10.1016/0014-2999(83)90473-9]
Abstract:
Microinjections of morphine in the rat periaqueductal gray matter (PAG) inhibited intestinal transit in linear relation to the log of the dose administered (in the range from 5 to 20 μg/rat). This linear regression was parallel with that obtained on intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) administration of morphine and the intracerebral (i.c.) route was calculated to be 4 times more potent than the i.c.v. route and 189 times more potent than the i.p. route. Monolateral electrolytic lesions into the PAG abolished the intestinal effect of i.c.v. morphine to a large extent. The relevance of other brain areas and the type of opiate receptors involved in this central effect of morphine are discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Intestinal transit; Morphine; Periaqueductal gray
Elenco autori:
M. Sala, D. Parolaro, G. Crema, L. Spazzi, G. Giagnoni, R. Cesana, E. Gori
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