Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status
Articolo
Data di Pubblicazione:
2010
Citazione:
Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status / S. Cauci, M. Di Santolo, K.K. Ryckman, S.M. Williams, G. Banfi. - In: BMC MEDICAL GENETICS. - ISSN 1471-2350. - 11:1(2010). [10.1186/1471-2350-11-29]
Abstract:
The interleukin-1 (IL-1) family of cytokines is involved in the inflammatory and repair reactions of skeletal muscle during and after exercise. Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes. Therefore, the IL-1 family cytokine genes are plausible candidate genes for athleticism. We explored whether IL-1 polymorphisms are associated with athlete status in European subjects.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Odds Ratio ; Gene Frequency ; Polymorphism, Genetic ; Humans ; Interleukin-1beta ; Muscle, Skeletal ; Phenotype ; Minisatellite Repeats ; Genotype ; Promoter Regions, Genetic ; Alleles ; Haplotypes ; Adult ; Introns ; Interleukin 1 Receptor Antagonist Protein ; Female ; Male ; Athletes
Elenco autori:
S. Cauci, M. Di Santolo, K.K. Ryckman, S.M. Williams, G. Banfi
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