Data di Pubblicazione:
1979
Citazione:
Chromosome lesions in amniotic fluid cell cultures / G. Simoni, L. Larizza, N. Sacchi, G. Della Valle, F. Dambrosio, L. De Carli. - In: HUMAN GENETICS. - ISSN 0340-6717. - 49:3(1979), pp. 327-332.
Abstract:
The frequencies of chromosome lesions were determined on 3537 mitoses in samples of varying sizes from cultures of 25 amniotic fluid specimens taken from patients at cytogenetic risk. The average percentage values of aberrant cells, including and excluding gaps, were 12.5 and 4.9, respectively. The corresponding values for fibroblasts and peripheral blood lymphocytes from normal adult donors, calculated under the same laboratory conditions, were 5.0 (including gaps) and 2.4 (excluding gaps) and 2.4 (including gaps) and 1.0 (excluding gaps), respectively. The hypothesis of a correlation between the increased incidence of chromosome lesions and the occurrence of abnormal karyotypes in amniotic fluid cell cultures is discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Karyotyping; Amniotic Fluid; Cells, Cultured; Humans; Chromosomes, Human; Chromosome Aberrations; Female; Pregnancy
Elenco autori:
G. Simoni, L. Larizza, N. Sacchi, G. Della Valle, F. Dambrosio, L. De Carli
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