Thermal behaviour and dissolution properties of naproxen in combinations with chemically modified ß-Cyclodextrins
Articolo
Data di Pubblicazione:
1992
Citazione:
Thermal behaviour and dissolution properties of naproxen in combinations with chemically modified ß-Cyclodextrins / G. Bettinetti, A. Gazzaniga, P. Mura, F. Giordano, M. Setti. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 18:1(1992), pp. 39-53.
Abstract:
Binary systems of naproxen with statistically-alkylated ßcyclodextrins (methyl, hydroxyethyl and hydroxypropyl derivatives) were investigated for both solid phase characterization (differential scanning calorimetry, X-ray powder diffraction) and dissolution properties (dispersed amount and rotating disc methods). Kneading, coevaporation and colyophilization of the 1:1 (mol/mol) naproxen/methyl ßcyclodextrin combination, as well as colyophilization of analogous combinations of naproxen with hydroxyethyl and hydroxypropyl ßcyclodextrin, led to amorphous products with higher dissolution rates than the corresponding physical mixtures. A conversion of crystalline to amorphous naproxen was also observed by heating the physical mixtures at about 393 K. The amorphous statistically-alkylated ßcyclodextrins, in particular methyl ßcyclodextrin, can be employed as amorphizing agents for crystalline naproxen.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Bettinetti, A. Gazzaniga, P. Mura, F. Giordano, M. Setti
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