Case report : use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura
Articolo
Data di Pubblicazione:
2012
Citazione:
Case report : use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura / L.A. Lotta, I. Mancini, G. Tuana, K.M. Musallam, F. Peyvandi. - In: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. - ISSN 0929-5305. - 34:3(2012 Oct), pp. 416-418. [10.1007/s11239-012-0717-7]
Abstract:
Thienopyridines are commonly used antiplatelet
drugs that may be associated with the development
of secondary, drug-induced thrombotic thrombocytopenic
purpura (TTP), a rare but potentially life threatening condition.
We report the case of a 70 year-old man with a
history of recurrent idiopathic TTP episodes who was
treated with clopidogrel and then ticlopidine for thromboprophylaxis
after percutaneous coronary intervention.
Treatment was successful with no signs of TTP recurrence.
Platelet counts and ADAMTS13 activity levels remained
normal for months after the initiation of anti-platelet
therapy, with no reappearance of anti-ADAMTS13 autoantibodies.
This report demonstrates that thienopyridines
do not necessarily induce TTP in patients with a history of
TTP who are in disease remission.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ADAMTS13; Clopidogrel; Drug-induced thrombotic thrombocytopenic purpura; Thrombotic thrombocytopenic purpura; Ticlopidine; VWF
Elenco autori:
L.A. Lotta, I. Mancini, G. Tuana, K.M. Musallam, F. Peyvandi
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