Data di Pubblicazione:
1997
Citazione:
Effects of amylin on human osteoblast-like cells / I. Villa, A. Rubinacci, F. Ravasi, A.F. Ferrara, F. Guidobono. - In: PEPTIDES. - ISSN 0196-9781. - 18:4(1997), pp. 537-540.
Abstract:
Amylin has been reported to have bone-conserving effects. In the present study we evaluated the possible activity of the peptide on human osteoblast-like (hOB) cells in primary culture. Amylin between 10(-9) and 10(-6) M, dose-dependently stimulated cell proliferation with a maximal effect (200%) at 10(-6) M. In addition, amylin increased osteocalcin production when hOB cells were exposed to 1,25(OH)2D3 (10(-8)M) but there was a nonsignificant upward trend on alkaline phosphatase activity. The present results suggest that amylin could be included among the group of peptides endowed with osteogenic activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alkaline phosphatase; Amylin; Osteoblast-like cells; Osteocalcin; Proliferation
Elenco autori:
I. Villa, A. Rubinacci, F. Ravasi, A.F. Ferrara, F. Guidobono
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