Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine
Articolo
Data di Pubblicazione:
1999
Citazione:
Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine / T. Grandi, F. Sparatore, A. Sparatore. - In: IL FARMACO. - ISSN 0014-827X. - 54:7(1999 Jul 30), pp. 479-485.
Abstract:
The title ketone, a supposed metabolite of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (MIQ), was prepared and found different on chromatographic comparison from the isolated metabolite M4. However, the pharmacological screening of this compound evidenced, among others, some interesting properties as inhibition of arachidonic acid induced platelet aggregation and protection from both hypobaric and cyanide induced hypoxia in mice. These activities suggest a possible cerebroprotective action to be further investigated.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Stomach Ulcer; Animals; Cyanides; Mice; Quinolizines; Neuroprotective Agents; Behavior, Animal; Anoxia; Indoles; Platelet Aggregation; Body Temperature; Anti-Ulcer Agents; Platelet Aggregation Inhibitors; Arachidonic Acid; Ethanol
Elenco autori:
T. Grandi, F. Sparatore, A. Sparatore
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