Data di Pubblicazione:
2001
Citazione:
2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine / A. Sparatore, F. Sparatore. - In: IL FARMACO. - ISSN 0014-827X. - 56:3(2001 Mar), pp. 169-174.
Abstract:
Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [3H]QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67-7.68.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals ; Chemistry, Physical ; Brain Chemistry ; Esters ; Magnetic Resonance Spectroscopy ; Spectrophotometry, Infrared ; Muscarinic Antagonists ; Rats ; Alkaloids ; Sparteine ; Physicochemical Phenomena ; Receptors, Muscarinic ; Quinuclidinyl Benzilate; Binding, Competitive ; Rats, Wistar ; Ligands ; Male
Elenco autori:
A. Sparatore, F. Sparatore
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