Data di Pubblicazione:
2012
Citazione:
Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction / B. De Chiara, V. Sedda, M. Parolini, J. Campolo, R. De Maria, R. Caruso, G. Pizzi, O. Disoteo, C. Dellanoce, A.R. Corno, G.M. Cighetti, O. Parodi. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - (2012).
Abstract:
We hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type. We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia,
hyperhomocysteinaemia, diabetes, obesity, and their combination). Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde. Twentyseven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in ≥3 RF. By multivariable ordinal regression
analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027–1.110, P = 0.002). Total RF burden is associated with increased total Cys levels. These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cardiovascular risk factors; lipid peroxidation; total plasma cysteine
Elenco autori:
B. De Chiara, V. Sedda, M. Parolini, J. Campolo, R. De Maria, R. Caruso, G. Pizzi, O. Disoteo, C. Dellanoce, A.R. Corno, G.M. Cighetti, O. Parodi
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