Data di Pubblicazione:
2001
Citazione:
Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation / L. Verotta, M. Guerrini, N. El-Sebakhy, A. Asaad, S. Toaima, M. Abou-Sheer, Y. Luo, J. Pezzuto. - In: FITOTERAPIA. - ISSN 1971-551X. - 72:8(2001), pp. 894-905.
Abstract:
From Astragalus peregrinus, four cycloartane-type saponins have been isolated and their structures elucidated by spectral means as 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-beta -D-glucopyranoside (1), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl-(1 -->4)-beta -D-glucopyranoside (2), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl(1 -->2)-beta -D-glucopyranoside (3) and 20(R),25-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,24(S)-tetrol (24-O-acetyl)- 3-O-alpha -L-rhamnopyranosyl-(1 -->2)-(6'-O-acetyl)-beta -D-glucopyranoside (4). Compounds 2 and 3 showed to stimulate the proliferation of mouse splenocytes and were not significantly cytotoxic. (C) 2001 Elsevier Science B.V. All rights reserved.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Verotta, M. Guerrini, N. El-Sebakhy, A. Asaad, S. Toaima, M. Abou-Sheer, Y. Luo, J. Pezzuto
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