Data di Pubblicazione:
1987
Citazione:
PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig / G. Brunelli, L. Daffonchio, A. Hernandez, A. Sala, C. Omini, F. Berti. - In: JOURNAL OF AUTONOMIC PHARMACOLOGY. - ISSN 0144-1795. - 7:3(1987), pp. 281-285.
Abstract:
1 A threshold dose of Prostaglandin D2 (PGD2) (0.5 microgram/kg i.v.), which did not modify the basal values of airway resistance, potentiated the acetylcholine induced bronchospasm in anaesthetized guinea-pigs. 2 beta-adrenoreceptors blockade induced by propranolol enhanced the positive interaction between PGD2 and acetylcholine in the pulmonary dynamics. 3 Active sensitization of guinea-pigs by ovalbumin increased the pulmonary PGD2-acetylcholine interaction and the phenomenon was sustained during the time. 4 The inability of PGD2 to potentiate histamine-induced bronchoconstriction suggests a specificity for the interaction.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Brunelli, L. Daffonchio, A. Hernandez, A. Sala, C. Omini, F. Berti
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