Inhibition of prostanoid synthesis protects against neuronal damage induced by focal ischemia in rat brain
Articolo
Data di Pubblicazione:
1998
Citazione:
Inhibition of prostanoid synthesis protects against neuronal damage induced by focal ischemia in rat brain / C. Buccellati, G. Folco, A. Sala, R. Scelsi, E. Masoero, P. Poggi, S. Govoni, L. Favalli, A. Rozza. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 257:3(1998), pp. 123-126.
Abstract:
Changes in prostanoids concentration and effects of the non-specific COX inhibitor indomethacin on prostanoids levels and extension of tissue damage were studied following focal ischemia induction in the fronto-parietal region of rat brain. Ischemia was induced in animals bearing a transcerebral microdialysis probe by injection of Rose Bengal, a photosensitive dye, followed by light activation. Prostanoid levels were determined in the dialysate using immunoenzymatic techniques. PGD2 levels rose significantly up to 237 ± 22 pg/ml compared to a basal level measured before ischemia induction which was below the detection limit. TXB2 changes were smaller and had a different time course. Treatment with indomethacin abolished the ischemia-induced PGD2 release and reduced the extent of injury to the area by 43 ± 3.7%. These results suggest that prostanoid release may play an important role in neurodegenerative processes and that cyclooxygenase inhibitors may contribute to protect against cerebral tissue damage.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Buccellati, G. Folco, A. Sala, R. Scelsi, E. Masoero, P. Poggi, S. Govoni, L. Favalli, A. Rozza
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