Data di Pubblicazione:
1990
Citazione:
REGULATION OF PROGESTERONE-RECEPTOR GENE-EXPRESSION / E. VEGETO, M. COCCIOLO, F. RASPAGLIESI, A. PIFFANELLI, R. FONTANELLI, A. MAGGI. - In: CANCER RESEARCH. - ISSN 0008-5472. - 50:17(1990), pp. 5291-5295.
Abstract:
The levels of progesterone receptor (PR) mRNA, PR protein, and [3H]R5020 binding activity were measured in parallel experiments conducted on a T47D subline expressing the estrogen receptor. A significant increase of PR mRNA levels could be detected within 6 h of exposure of the cells to estradiol (10-8 M). The changes in mRNA, however, did not lead to any variation of PR protein levels of [3H]R5020 binding activity. A parallel analysis of PR mRNA and [3H]R5020 binding was then performed in a series of tumor biopsies. In estrogen receptor-positive and PR-positive tissues a correlation among the two values was found. It is postulated that the above mentioned data could reflect the existence of a difference in the mechanisms controlling the numerous steps of the PR synthesis in the various hormone-responsive tissues. This variability could allow an organ-specific response to the cyclic changes of circulating hormone.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. VEGETO, M. COCCIOLO, F. RASPAGLIESI, A. PIFFANELLI, R. FONTANELLI, A. MAGGI
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