In vitro and in vivo evaluation of oral systems for time and site specific delivery of drugs (Chronotopic technology)
Articolo
Data di Pubblicazione:
1999
Citazione:
In vitro and in vivo evaluation of oral systems for time and site specific delivery of drugs (Chronotopic technology) / M.E. Sangalli, A. Maroni, C. Busetti, L. Zema, F. Giordano, A. Gazzaniga. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 138:3(1999 Mar), pp. 68-73.
Abstract:
This paper reports the in vivo and in vitro evaluation of an oral system for time and/or site specific drug delivery prepared according to Chronotopic technology. The proposed device consists of a drug containing core coated by a hydrophilic polymeric layer, which determines the delay in release onset. By applying an outer gastroresistant film, and by properly modulating the delay duration, a colon-specific release can be achieved. The obtained results show that the proposed delivery system is capable of releasing drug after a programmed time (time-specific release) and of targeting the colon (site-specific release) when an external gastroresistant film is applied on units coated with an appropriate amount of a hydrophilic retarding polymer.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Drug Delivery Systems ; Antipyrine ; Colon ; Delayed-Action Preparations ; Humans; Adult ; Anti-Inflammatory Agents, Non-Steroidal ; Male
Elenco autori:
M.E. Sangalli, A. Maroni, C. Busetti, L. Zema, F. Giordano, A. Gazzaniga
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