Polymorphism ofrac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF 1035). I. Thermal, spectroscopic, and X-ray diffraction properties
Articolo
Data di Pubblicazione:
2001
Citazione:
Polymorphism ofrac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF 1035). I. Thermal, spectroscopic, and X-ray diffraction properties / F. Giordano, A. Rossi, J.R. Moyano, A. Gazzaniga, V. Massarotti, M. Bini, D. Capsoni, T. Peveri, E. Redenti, L. Carima, M.D. Alberi, M. Zanol. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 90:8(2001), pp. 1154-1163.
Abstract:
The polymorphism of rac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF 1035) was investigated. Three different crystal forms (Form I, Form II, and Form III) were obtained by recrystallization procedures from common organic solvents. The polymorphs were characterized by Raman and carbon-13 nuclear magnetic resonance (13C NMR) spectroscopy, in solution and in solid state (cross polarization-magic angle spinning), powder X-ray diffractometry, and thermal methods (differential scanning calorimetry, hot stage microscopy, and thermogravimetry). Moreover, the diffraction patterns of Form I, collected at controlled temperatures, gave evidence of the presence of two reversible structural rearrangements at ∼60 and ∼75°C. These structural variations were confirmed by the results obtained by differential scanning calorimetry and hot stage microscopy techniques. The analysis of the Raman spectra allowed the identification of peculiar absorption bands for each polymorph. Form III was the stable crystal form at room temperature as determined by the basis of slurry conversion method.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
2-Aminotetralin derivative; Polymorphism; Racemic compound; Spectroscopic properties; Thermal properties
Elenco autori:
F. Giordano, A. Rossi, J.R. Moyano, A. Gazzaniga, V. Massarotti, M. Bini, D. Capsoni, T. Peveri, E. Redenti, L. Carima, M.D. Alberi, M. Zanol
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