Modulation of the immune response by plasma protease inhibitors III. Alpha 1-antichymotrypsin inhibits human natural killing and antibody-dependent cell-mediated cytotoxicity
Articolo
Data di Pubblicazione:
1982
Citazione:
Modulation of the immune response by plasma protease inhibitors III. Alpha 1-antichymotrypsin inhibits human natural killing and antibody-dependent cell-mediated cytotoxicity / P. Gravagna, E. Gianazza, P. Arnaud, M. Neels, E.W. Ades. - In: JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY. - ISSN 0033-6890. - 32:2(1982 Aug), pp. 125-130.
Abstract:
The effects of alpha 1-antichymotrypsin (AChy), a serum protease inhibitor, on two parameters of the cellular immune response, natural killing (NK) and antibody-dependent cell-mediated cytotoxicity (ADCC), were tested. Both NK and ADCC were inhibited by the protein in a dose-dependent fashion. Our results suggest that this protease inhibitor binds to the surface of NK and ADCC target cells and neutralizes the lytic signal passed between the effector and target.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antibody-Dependent Cell Cytotoxicity ; Immunity, Cellular ; Immunoelectrophoresis ; Dose-Response Relationship, Drug ; Killer Cells, Natural ; Humans ; Adult ; alpha 1-Antichymotrypsin ; Antibody Formation ; Chymotrypsin
Elenco autori:
P. Gravagna, E. Gianazza, P. Arnaud, M. Neels, E.W. Ades
Link alla scheda completa: