Relationships between conformational behaviour and binding affinity towards beta1 and beta2 adrenoceptors of some chiral phenoxypropanolamines with bulky N-substituents
Articolo
Data di Pubblicazione:
1995
Citazione:
Relationships between conformational behaviour and binding affinity towards beta1 and beta2 adrenoceptors of some chiral phenoxypropanolamines with bulky N-substituents / L. Villa, A.M. Villa, M. Pallavicini, S. Romeo, E. Valoti, V. Ferri, E. Iuliano, N. Brunello. - In: IL FARMACO. - ISSN 0014-827X. - 50:10(1995), pp. 643-658.
Abstract:
The optical isomers of a series of phenoxypropanolamine compounds with N-substituents bulkier than isopropyl have been synthesized, and their binding affinity towards β1 and β2-adrenoceptors has been determined. A computational study, including a Molecular Dynamics (MD) simulation and quenching in water and a GRID analysis provided some useful suggestions for possible interpretation patterns for the different affinity exhibited by the compounds studied.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Receptor subtype specificity; adrenergic-receptor; clocking-agents; antagonists; beta-1 adrenoreceptor; derivates; agonists; cloning; invitro; ligands
Elenco autori:
L. Villa, A.M. Villa, M. Pallavicini, S. Romeo, E. Valoti, V. Ferri, E. Iuliano, N. Brunello
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