Data di Pubblicazione:
2012
Citazione:
Oral colon delivery of insulin with the aid of functional adjuvants / A. Maroni, L. Zema, M. D. Del Curto, A. Foppoli, A. Gazzaniga. - In: ADVANCED DRUG DELIVERY REVIEWS. - ISSN 0169-409X. - 64:6(2012), pp. 540-556. [10.1016/j.addr.2011.10.006]
Abstract:
Oral colon delivery is currently considered of importance not only for the treatment of local pathologies, such as primarily inflammatory bowel disease (IBD), but also as a means of accomplishing systemic therapeutic goals. Although the large bowel fails to be ideally suited for absorption processes, it may indeed offer a number of advantages over the small intestine, including a long transit time, lower levels of peptidases and higher responsiveness to permeation enhancers. Accordingly, it has been under extensive investigation as a possible strategy to improve the oral bioavailability of peptide and protein drugs. Because of a strong underlying rationale, most of these studies have focused on insulin. In the present review, the impact of key anatomical and physiological characteristics of the colon on its viability as a protein release site is discussed. Moreover, the main formulation approaches to oral colon targeting are outlined along with the design features and performance of insulin-based devices.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bioavailabilty; Formulation; Insulin; Oral colon delivery; Peptide; Protein
Elenco autori:
A. Maroni, L. Zema, M.D. Del Curto, A. Foppoli, A. Gazzaniga
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