Data di Pubblicazione:
1990
Citazione:
RED-CELL AGING AND ACTIVE CALCIUM-TRANSPORT / M. SAMAJA, A. RUBINACCI, R. MOTTERLINI, A. DEPONTI, N. PORTINARO. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - 25:3-4(1990), pp. 279-286. [10.1016/0531-5565(90)90063-8]
Abstract:
The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
active calcium transport; calcium homeostasis; inside-out vesicles; oxidative damage; red cell aging; red cell density
Elenco autori:
M. Samaja, A. Rubinacci, R. Motterlini, A. Deponti, N. Portinaro
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