Data di Pubblicazione:
2012
Citazione:
Novel insight into stem cell trafficking in dystrophic muscles / A. Farini, C. Villa, A. Manescu, F. Fiori, A. Giuliani, P. Razini, C. Sitzia, G. Del Fraro, M. Belicchi, M. Meregalli, F. Rustichelli, Y. Torrente. - In: INTERNATIONAL JOURNAL OF NANOMEDICINE. - ISSN 1176-9114. - 2012:7(2012 May), pp. 3059-3067. [10.2147/IJN.S30595]
Abstract:
Recently published reports have described possible cellular therapy approaches
to regenerate muscle tissues using arterial route delivery. However, the kinetic of distribution
of these migratory stem cells within injected animal muscular dystrophy models is unknown.
Using living X-ray computed microtomography, we established that intra-arterially injected
stem cells traffic to multiple muscle tissues for several hours until their migration within dystrophic
muscles. Injected stem cells express multiple traffic molecules, including VLA-4, LFA-1,
CD44, and the chemokine receptor CXCR4, which are likely to direct these cells into dystrophic
muscles. In fact, the majority of intra-arterially injected stem cells access the muscle tissues
not immediately after the injection, but after several rounds of recirculation. We set up a new,
living, 3D-imaging approach, which appears to be an important way to investigate the kinetic
of distribution of systemically injected stem cells within dystrophic muscle tissues, thereby
providing supportive data for future clinical applications
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
iron nanoparticles ; micro-CT ; CD133+ stem cells ; dystrophic muscles
Elenco autori:
A. Farini, C. Villa, A. Manescu, F. Fiori, A. Giuliani, P. Razini, C. Sitzia, G. Del Fraro, M. Belicchi, M. Meregalli, F. Rustichelli, Y. Torrente
Link alla scheda completa: