Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation
Articolo
Data di Pubblicazione:
1989
Citazione:
Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation / A. Gianni, S. Siena, M. Bregni, C. Tarella, A. C. Stern, A. Pileri, G. Bonadonna. - In: THE LANCET. - ISSN 0140-6736. - 2:8663(1989 Sep 09), pp. 580-585. [10.1016/S0140-6736(89)90711-3]
Abstract:
Granulocyte-macrophage colony-stimulating factor (GM-CSF), given to accelerate recovery from cytopenia induced by high-dose (7 g/m2) cyclophosphamide, reproducibly brought about a dramatic increase (up to 1000-fold) in the number of peripheral blood granulocyte-macrophage colony-forming units (CFU-GM). These circulating progenitors were harvested by leucapheresis and reinfused, together with autologous bone marrow cells, in seven patients with cancer after total body irradiation and melphalan. Complete haemopoietic recovery occurred in all seven transplanted patients in a very short time: mean (SD) 9.1 (0.9) days (range 8-11) to achieve more than 0.5 x 10(9)/l neutrophils, 9.9 (1.7) days (range 8-13) to over 1 x 10(9)/l neutrophils, 10.7 (2.6) days (range 9-16) to over 0.5 x 10(11)/l platelets, and 13.6 (4.2) days (range 13-21) to over 1.0 x 10(11)/l platelets. A reduction in the severity of mucositis was also observed. The rapid haematological recovery made possible by this approach promises to increase the therapeutic index of high-dose chemoradiotherapy regimens and to widen their role as treatment for chemoradiosensitive tumours.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hematopoietic Stem Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Colony-Stimulating Factors; Humans; Cyclophosphamide; Leukocyte Count; Evaluation Studies as Topic; Neutrophils; Adult; Hematopoietic Stem Cell Transplantation; Lymphoma; Time Factors; Male; Blood Transfusion, Autologous; Drug Administration Schedule; Leukapheresis; Infusions, Intravenous; Combined Modality Therapy; Recombinant Proteins; Growth Substances; Hematopoiesis; Middle Aged; Leukopenia; Female; Platelet Count
Elenco autori:
A. Gianni, S. Siena, M. Bregni, C. Tarella, A. C. Stern, A. Pileri, G. Bonadonna
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