GM-CSF-exposed peripheral blood progenitors as sole source of stem cells for autologous transplantation in two patients with multiple myeloma
Articolo
Data di Pubblicazione:
1990
Citazione:
GM-CSF-exposed peripheral blood progenitors as sole source of stem cells for autologous transplantation in two patients with multiple myeloma / A. Pileri, C. Tarella, M. Bregni, M. Boccadoro, S. Siena, D. Caracciolo, G. Bonadonna, A.M. Gianni. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 75:Suppl 1(1990), pp. 79-82.
Abstract:
Two patients (aged 52 and 44) received high-dose sequential chemotherapy followed by myeloablative therapy and autotransplantation as first line treatment of a stage III multiple myeloma with high plasmacell labelling index. Autograft was performed with peripheral blood cells collected after high-dose etoposide followed by rhGM-CSF continuous infusion. During this period very high numbers of circulating hemopoietic progenitors were detected in both patients. Prompt, complete and durable hematological recovery was observed after autograft with peripheral blood stem cells. Thus, we conclude that massively released progenitors after high-dose chemotherapy and rhGM-CSF include stem cells capable of marrow reconstitution.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Blood Transfusion, Autologous ; Hematopoietic Stem Cells ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Growth Substances ; Colony-Stimulating Factors ; Adult ; Hematopoietic Stem Cell Transplantation ; Middle Aged ; Male ; Female ; Multiple Myeloma
Elenco autori:
A. Pileri, C. Tarella, M. Bregni, M. Boccadoro, S. Siena, D. Caracciolo, G. Bonadonna, A.M. Gianni
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