Oral lichen planus in patients infected or noninfected with hepatitis C virus : the role of autoimmunity
Articolo
Data di Pubblicazione:
1999
Citazione:
Oral lichen planus in patients infected or noninfected with hepatitis C virus : the role of autoimmunity / M. Carrozzo, S. Gandolfo, G. Lodi, M. Carbone, P. Garzino-Demo, C. Carbonero, S.R. Porter, C. Scully. - In: JOURNAL OF ORAL PATHOLOGY & MEDICINE. - ISSN 0904-2512. - 28:1(1999 Jan), pp. 16-19.
Abstract:
Serum proteins, serum immunoglobulins, anti-nuclear antibodies (ANA), anti-smooth muscle antibodies (ASMA), anti-mitochondrial antibodies (AMA), anti-liver-kidney antibodies (LKM), anti-parietal-cell gastric antibodies (APCA), anti-epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP-HCV+ve subjects and in a comparable group of 23 who were OLP-HCV-ve. In addition, all the patients with chronic liver disease who were sero-positive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP-HCV+ve than in OLP-HCV-ve (P = 0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV-ve (respectively, P = 0.017 and P = 0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP-HCV+ve and OLP-HCV-ve patients. Overall, immunologically-related abnormalities were found in 17(63%) OLP-HCV+ve and 11(48%) OLP-HCV-ve (P = 0.43) patients. Three OLP-HCV-ve and no OLP-HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune-responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Liver Diseases ; Autoimmunity ; Mitochondria ; Parietal Cells, Gastric ; Hypergammaglobulinemia ; Muscle, Smooth ; Aged, 80 and over ; Hepatitis C ; Lichen Planus, Oral ; Antibodies, Antinuclear ; Blood Proteins ; Cryoglobulins ; Immunoglobulin A ; Epithelial Cells ; Autoantibodies ; Immunoglobulin G ; Kidney ; Liver ; Immunoglobulin M
Elenco autori:
M. Carrozzo, S. Gandolfo, G. Lodi, M. Carbone, P. Garzino Demo, C. Carbonero, S.R. Porter, C. Scully
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