Sulfanyl-methylene-5(4H)-oxazolones and β-sulfanyl-α-nitroacrylates as appealing dienophiles for the synthesis of conformationally constrained cysteine analogues
Articolo
Data di Pubblicazione:
2012
Citazione:
Sulfanyl-methylene-5(4H)-oxazolones and β-sulfanyl-α-nitroacrylates as appealing dienophiles for the synthesis of conformationally constrained cysteine analogues / A. Ruffoni, A. Casoni, S. Pellegrino, M.L. Gelmi, R. Soave, F. Clerici. - In: TETRAHEDRON. - ISSN 0040-4020. - 68:7(2012), pp. 1951-1962. [10.1016/j.tet.2011.12.052]
Abstract:
A new class of masked constrained cysteine derivatives containing the norbornen/ane scaffold were prepared by the way of Diels-Alder cycloaddition reaction by exploitation of two different dienophiles, sulfanyl-methylene-5(4H)- oxazolones and β-sulfanyl-α-nitroacrylates. The new norbornen/ane amino acid derivatives can be considered versatile building blocks due to the presence of the α,α-disubstituted amino acid function, suitable for peptide synthesis, but also by the carbon-carbon norbornene double bond, which could be variously functionalized.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Ruffoni, A. Casoni, S. Pellegrino, M.L. Gelmi, R. Soave, F. Clerici
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