Molecular characterization of rotavirus strains from children with acute gastroenteritis (Lombardy, 2008-2010)
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Data di Pubblicazione:
2011
Citazione:
Molecular characterization of rotavirus strains from children with acute gastroenteritis (Lombardy, 2008-2010) / S. Binda, M. Gambino, L. Pellegrinelli, R. Delogu, G. Ianiro, M. Barbi, L. Bubba, A. Mammoliti, V. Primache, F.M. Ruggeri, L. Fiore. ((Intervento presentato al 4. convegno European Rotavirus Biology Meeting tenutosi a Villa San Giovanni (RC) nel 2011.
Abstract:
As part of the RotaNet-Italy Study Group, the Italian component of the EuroRotaNet, in the period 2008-2010 we gathered the stool
samples of 370 children (age: rus commercial rapid test. The molecular characterization of rotavirus strains was performed at ISS,
which is the coordinator of the rotavirus surveillance project in Italy [Ruggeri, 2011]. Approximately 1% of all samples were
negative and were detected only in the 2008-2009 season. In all three years, the most frequent combination was G1P[8] (45%,
range: 36-53%). The other “common” genotypes observed were: G9P[8] (25%, range: 20-28%), G4P[8] (13%, range: 7-16%),
G3P[8] (6%, range: 4-8%) and G2P[4] (4%, range: 2-5%), according to data from other Italian regions and European countries.
“Uncommon” associations were detected only in 2008-2009: two G10P[8], one G2P[8]. Mixed infections were frequent, being
identified in average 8% of cases (range: 6-9%) over the years and “common” G1 and P[8] types were mostly involved. Since new
strains could have antigenic and virulence characteristics that could cause more severe diseases, it is important to investigate the
nature of these associations. Therefore it is necessary to carry on and improve, through increased adhesion, the RotaNet programs of
circulating strains monitoring both for epidemiological surveillance and vaccine implementation. References. [1] Ruggeri F.M.,
Delogu R., Petouchoff T., Tcheremenskaia O., De Petris S., Fiore L., and the RotaNet-Italy Study Group, Molecular
characterization of rotavirus strains from children with diarrhea in Italy, 2007-2009. J. Med. Virol., 2011; In press.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
rotavirus ; molecular characterization ; RotaNet
Elenco autori:
S. Binda, M. Gambino, L. Pellegrinelli, R. Delogu, G. Ianiro, M. Barbi, L. Bubba, A. Mammoliti, V. Primache, F.M. Ruggeri, L. Fiore
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