Data di Pubblicazione:
1993
Citazione:
Identification of four epitopes in hepatitis C virus core protein / P. Ferroni, G. Mascolo, M. Zaninetti, D. Colzani, F. Pregliasco, M. Pirisi, F. Barbone, V. Gasparini. - In: JOURNAL OF CLINICAL MICROBIOLOGY. - ISSN 0095-1137. - 31:6(1993 Jun), pp. 1586-1591.
Abstract:
We identified four epitopes in hepatitis C virus core protein by using the algorithm of Jameson and Wolf. G15V (amino acids [aa] 31 to 45) appears to be the immunodominant epitope, since it was able to detect antibodies to the core protein in all 40 patients and in 44 of 45 recombinant immunoblot assay-confirmed positive blood donors. This epitope is associated with a low frequency of false-positive results, as found with 522 negative blood donors. A strong reactivity was also observed with the Q15V epitope (aa 7 to 21), although this was associated with low specificity. Occasional reactivity to the R15P (aa 49 to 63) and P15R (aa 99 to 113) epitopes was observed. Q15V and G15V detected antibodies to core protein earlier than the other two epitopes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hepacivirus ; Humans ; Algorithms ; Hepatitis Antibodies ; Antigens, Viral ; Amino Acid Sequence ; Blood Donors ; Viral Core Proteins ; Molecular Sequence Data ; Enzyme-Linked Immunosorbent Assay ; Peptides ; Hepatitis C ; Hepatitis C Antibodies ; Epitopes
Elenco autori:
P. Ferroni, G. Mascolo, M. Zaninetti, D. Colzani, F. Pregliasco, M. Pirisi, F. Barbone, V. Gasparini
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