Sialic acid and GM3 ganglioside expression in some papillomavirus-associated rinary bladder tumours of cattle
Articolo
Data di Pubblicazione:
2007
Citazione:
Sialic acid and GM3 ganglioside expression in some papillomavirus-associated rinary bladder tumours of cattle / S. Roperto, G. Borzacchiello, R. Casellato, P. Galati, V. Russo, S. Sonnino, F. Roperto. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 137:2-3(2007), pp. 87-93. [10.1016/j.jcpa.2007.03.008]
Abstract:
This study was based on 30 papillomavirus-associated urinary bladder tumours from cattle with chronic haematuria, the animals having been kept since birth on pasture rich in bracken fern. The ganglioside content was assessed and compared with that of normal bovine urinary bladders, which was shown to be 28.6±3.3 (mean±SD) μg of lipid-bound sialic acid per gram of fresh tissue. In neoplastic bladder samples this value was higher but variable (120.9±80.6 in benign tumours, and 94.7±45.7 in malignant tumours). The main ganglioside, GM3, represented ca 75% of the total ganglioside mixture in normal tissues and 50-80% in tumour samples. GM1, GM2, GD1a, GD3 and FucGM1 were found as minor components. The study suggested that GM3 ganglioside may have a crucial role in "downregulation" of the metastatic potential of bovine urothelial cancers.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Roperto, G. Borzacchiello, R. Casellato, P. Galati, V. Russo, S. Sonnino, F. Roperto
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