Data di Pubblicazione:
2011
Citazione:
Remodeling of sphingolipids by plasma membrane associated enzymes / M. Aureli, N. Loberto, V. Chigorno, A. Prinetti, S. Sonnino. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - 36:9(2011), pp. 1636-1644.
Abstract:
The sphingolipid plasma membrane content and pattern is the result of several processes, among which the main, in term of quantity, are: Neo-biosynthesis in endoplasmic reticulum and Golgi apparatus, membrane turnover with final catabolism in lysosomes and membrane shedding. In addition to this, past and recent data suggest that the head group of sphingolipids can be opportunely modified at the plasma membrane level, probably inside specific membrane lipid domains, by the action of enzymes involved in the sphingolipids metabolism, working directly at the cell surface. The number of membrane enzymes, hydrolases and transferases, acting on membrane sphingolipids is growing very rapidly. In this report we describe some properties of these enzymes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Glycosyltranferases; Hydrolases; Lipid rafts; Plasma membrane; Sphingolipids; Sphingomyelin synthase
Elenco autori:
M. Aureli, N. Loberto, V. Chigorno, A. Prinetti, S. Sonnino
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