Lactate detection in the brain of growth-restricted fetuses with magnetic resonance spectroscopy
Articolo
Data di Pubblicazione:
2011
Citazione:
Lactate detection in the brain of growth-restricted fetuses with magnetic resonance spectroscopy / I. Cetin, B. Barberis, V. Brusati, E. Brighina, L. Mandia, A. Arighi, T. Radaelli, P. Biondetti, N. Bresolin, G. Pardi, M. Rango. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - 205:4(2011 Oct), pp. 350.e1-350.e7. [10.1016/j.ajog.2011.06.020]
Abstract:
OBJECTIVE: The objective of the study was to determine the feasibility
of detecting fetal brain lactate, a marker of fetal metabolic acidemia,
using a noninvasive technique, proton magnetic resonance spectroscopy
(1H MRS), in intrauterine growth-restricted (IUGR) fetuses.
STUDY DESIGN: In vivo human fetal brain lactate detection was determined
by 1H MRS in 5 fetuses with IUGR. Oxygenation and acid-base
balance data were obtained at birth.
RESULTS: 1H MRS analysis showed the presence of a lactate peak in
the brain of the most severely affected IUGR fetus, with abnormal umbilical
artery Doppler and fetal heart rate tracing. This finding was consistent
with the low oxygen content and high lactic acid concentration observed
in umbilical blood obtained at delivery.
CONCLUSION: 1H MRS allows the noninvasive detection of cerebral
lactate in IUGR fetuses. Lactate detected by 1H MRS may represent a
possible marker of in utero cerebral injury or underperfusion.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Brain sparing; Fetal brain metabolism; Fetal distress; Placental insufficiency; Pregnancy
Elenco autori:
I. Cetin, B. Barberis, V. Brusati, E. Brighina, L. Mandia, A. Arighi, T. Radaelli, P. Biondetti, N. Bresolin, G. Pardi, M. Rango
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